Individuals at increased risk for development of bipolar disorder display structural alterations similar to people with manifest disease.

ABSTRACT: In psychiatry, there has been a growing focus on identifying at-risk populations. For schizophrenia, these efforts have led to the development of early recognition and intervention measures. Despite a similar disease burden, the populations at risk of bipolar disorder have not been sufficiently characterized. Within the BipoLife consortium, we used magnetic resonance imaging (MRI) data from a multicenter study to assess structural gray matter alterations in N = 263 help-seeking individuals from seven study sites. We defined the risk using the EPIbipolar assessment tool as no-risk, low-risk, and high-risk and used a region-of-interest approach (ROI) based on the results of two large-scale multicenter studies of bipolar disorder by the ENIGMA working group. We detected significant difference

SUBMITTER: Mikolas P 

PROVIDER: S-EPMC8452775 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature