Differential Modulation of the Voltage-Gated Na⁺ Channel 1.6 by Peptides Derived From Fibroblast Growth Factor 14.

ABSTRACT: The voltage-gated Na⁺ (Nav) channel is a primary molecular determinant of the initiation and propagation of the action potential. Despite the central role of the pore-forming α subunit in conferring this functionality, protein:protein interactions (PPI) between the α subunit and auxiliary proteins are necessary for the full physiological activity of Nav channels. In the central nervous system (CNS), one such PPI occurs between the C-terminal domain of the Nav1.6 channel and fibroblast growth factor 14 (FGF14). Given the primacy of this PPI in regulating the excitability of neurons in clinically relevant brain regions, peptides targeting the FGF14:Nav1.6 PPI interface could be of pre-clinical value. In this work, we pharmacologically evaluated peptides derived from FGF14 that cor

SUBMITTER: Singh AK 

PROVIDER: S-EPMC8452925 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature