Frailty and Clinical Outcomes of Direct Oral Anticoagulants Versus Warfarin in Older Adults With Atrial Fibrillation : A Cohort Study.

ABSTRACT:

Background

The role of differing levels of frailty in the choice of oral anticoagulants for older adults with atrial fibrillation (AF) is unclear.

Objective

To examine the outcomes of direct oral anticoagulants (DOACs) versus warfarin by frailty levels.

Design

1:1 propensity score-matched analysis of Medicare data, 2010 to 2017.

Setting

Community.

Patients

Medicare beneficiaries with AF who initiated use of dabigatran, rivaroxaban, apixaban, or warfarin.

Measurements

Composite end point of death, ischemic stroke, or major bleeding by frailty levels, defined by a claims-based frailty index.

Results

In the dabigatran-warfarin cohort (n = 158 730; median follow-up, 72 days), the event rate per 1000 person-years was 63.5 for dabigatran i

SUBMITTER: Kim DH 

PROVIDER: S-EPMC8453126 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature