The Significance of MET Expression and Strategies of Targeting MET Treatment in Advanced Gastric Cancer.

ABSTRACT:

Background

Accurate assessment of predictive biomarker expression is critical in patient selection in clinical trials or clinical practice. However, changes in biomarker expression may occur after treatment. The aim of the present study was to evaluate the effects of chemotherapy on MET expression in gastric cancer (GC).

Methods

MET expression was examined immunohistochemically before and after treatment in 122 patients with unresectable or recurrent GC, and was evaluated according to H-score or the scoring criteria used in the MetMAb trial. MET gene amplification was assessed by chromogenic in situ hybridization (CISH). The antitumor effect of MET targeted therapy was investigated in human gastric cancer cells in vitro and in vivo, and the underl

SUBMITTER: Liao H 

PROVIDER: S-EPMC8453156 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature