Effect of Preemptive Intervention on Developmental Outcomes Among Infants Showing Early Signs of Autism: A Randomized Clinical Trial of Outcomes to Diagnosis.

ABSTRACT:

Importance

Intervention for individuals with autism spectrum disorder (ASD) typically commences after diagnosis. No trial of an intervention administered to infants before diagnosis has shown an effect on diagnostic outcomes to date.

Objective

To determine the efficacy of a preemptive intervention for ASD beginning during the prodromal period.

Design, setting, and participants

This 2-site, single rater-blinded randomized clinical trial of a preemptive intervention vs usual care was conducted at 2 Australian research centers (Perth, Melbourne). Community sampling was used to recruit 104 infants aged 9 to 14 months showing early behaviors associated with later ASD, as measured by the Social Attention and Communication Surveillance-Revised. Recruitment occurred from June

SUBMITTER: Whitehouse AJO 

PROVIDER: S-EPMC8453361 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature