Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephalitis: A Meta-analysis.

ABSTRACT:

Importance

Overall, immunotherapy has been shown to improve outcomes and reduce relapses in individuals with N-methyl-d-aspartate receptor (NMDAR) antibody encephalitis (NMDARE); however, the superiority of specific treatments and combinations remains unclear.

Objective

To map the use and safety of immunotherapies in individuals with NMDARE, identify early predictors of poor functional outcome and relapse, evaluate changes in immunotherapy use and disease outcome over the 14 years since first reports of NMDARE, and assess the Anti-NMDAR Encephalitis One-Year Functional Status (NEOS) score.

Data sources

Systematic search in PubMed from inception to January 1, 2019.

Study selection

Published articles including patients with NMDARE with positive NMDAR antibodies a

SUBMITTER: Nosadini M 

PROVIDER: S-EPMC8453367 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature