Germline transmission of donor, maternal and paternal mtDNA in primates.

ABSTRACT:

Study question

What are the long-term developmental, reproductive and genetic consequences of mitochondrial replacement therapy (MRT) in primates?

Summary answer

Longitudinal investigation of MRT rhesus macaques (Macaca mulatta) generated with donor mtDNA that is exceedingly distant from the original maternal counterpart suggest that their growth, general health and fertility is unremarkable and similar to controls.

What is known already

Mitochondrial gene mutations contribute to a diverse range of incurable human disorders. MRT via spindle transfer in oocytes was developed and proposed to prevent transmission of pathogenic mtDNA mutations from mothers to children.

Study design, size, duration

The study provides longitudinal studies on general health, fertility

SUBMITTER: Ma H 

PROVIDER: S-EPMC8453408 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature