Type of menopause, age of menopause and variations in the risk of incident cardiovascular disease: pooled analysis of individual data from 10 international studies.

ABSTRACT:

Study question

How does the risk of cardiovascular disease (CVD) vary with type and age of menopause?

Summary answer

Earlier surgical menopause (e.g. <45 years) poses additional increased risk of incident CVD events, compared to women with natural menopause at the same age, and HRT use reduced the risk of CVD in women with early surgical menopause.

What is known already

Earlier age at menopause has been linked to an increased risk of CVD mortality and all-cause mortality, but the extent that this risk of CVD varies by type of menopause and the role of postmenopausal HRT use in reducing this risk is unclear.

Study design, size, duration

Pooled individual-level data of 203 767 postmenopausal women from 10 observational studies that contribute to the International

SUBMITTER: Zhu D 

PROVIDER: S-EPMC8453420 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature