The rs74794265 SNP of the SREK1 Gene is Associated with COPD in Kashi, China.

ABSTRACT:

Background

Kashi city is situated near the Taklamakan desert and has a high incidence rate of chronic obstructive pulmonary disease (COPD). In this study, we aimed to explore the relationship between the SNP of the SREK1 gene locus rs74794265 and the susceptibility to COPD among the Uyghur population in Kashi, XinJiang, China.

Methods

A total of 541 patients with COPD and 534 control subjects were included in this study. Sanger sequencing was used to analyze the SNP of the SREK1 gene locus rs74794265 site. The distribution of genotypes in different genetic models between the case and control group were analyzed by logistic regression analysis after adjusting for age, sex, and smoking history.

Results

The SREK1 gene SNP locus rs74794265 included tw

SUBMITTER: Abudureheman Z 

PROVIDER: S-EPMC8453436 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature