Pre-exposure to hydrogen sulfide modulates the innate inflammatory response to organic dust.

ABSTRACT: Animal production units produce and store many contaminants on-site, including organic dust (OD) and hydrogen sulfide (H₂S). Workers in these settings report various respiratory disease symptoms. Both OD and H₂S have shown to induce lung inflammation. However, impact of co-exposure to both H₂S and OD has not been investigated. Therefore, we tested a hypothesis that pre-exposure to H₂S modulates the innate inflammatory response of the lungs to organic dust. In a mouse model of H₂S and organic dust extract (ODE) exposure, we assessed lung inflammation quantitatively. We exposed human airway epithelial and monocytic cells to medium or H₂S alone or H₂S followed by ODE and measured cell viability, oxidative stress, and

SUBMITTER: Shrestha D 

PROVIDER: S-EPMC8453448 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature