Dataset Information

Longitudinal Analysis of Multiple Neurotransmitter Metabolites in Cerebrospinal Fluid in Early Parkinson's Disease.

ABSTRACT:

Background

Cerebrospinal fluid (CSF) levels of monoamine metabolites may represent biomarkers of Parkinson's disease (PD).

Objective

The aim of this study was quantification of multiple metabolites in CSF from PD versus healthy control subjects (HCs), including longitudinal analysis.

Methods

Absolute levels of multiple monoamine metabolites in CSF were quantified by liquid chromatography coupled with tandem mass spectrometry from 161 individuals with early PD and 115 HCs from the Parkinson's Progression Marker Initiative and de novo PD (DeNoPA) studies.

Results

Baseline levels of homovanillic acid (HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC) were lower in individuals with PD compared with HCs. HVA levels correlated with Movement Disorder Society Unified Parkinson's Disease Rating Scale total scores (P < 0.01). Both HVA/dopamine and DOPAC/dopamine levels correlated with caudate nucleus and raw DOPAC with putamen dopamine transporter single-photon emission computed tomography uptake ratios (P < 0.01). No metabolite changed over 2 years in drug-naive individuals, but some changed on starting levodopa treatment.

Conclusions

HVA and DOPAC CSF levels mirrored nigrostriatal pathway damage, confirming the central role of dopaminergic degeneration in early PD. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

SUBMITTER: Kremer T

PROVIDER: S-EPMC8453505 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Publications

Longitudinal Analysis of Multiple Neurotransmitter Metabolites in Cerebrospinal Fluid in Early Parkinson's Disease.

Kremer Thomas T Taylor Kirsten I KI Siebourg-Polster Juliane J Gerken Thomas T Staempfli Andreas A Czech Christian C Dukart Juergen J Galasko Douglas D Foroud Tatiana T Chahine Lana M LM Coffey Christopher S CS Simuni Tanya T Weintraub Daniel D Seibyl John J Poston Kathleen L KL Toga Arthur W AW Tanner Caroline M CM Marek Kenneth K Hutten Samantha J SJ Dziadek Sebastian S Trenkwalder Claudia C Pagano Gennaro G Mollenhauer Brit B

Movement disorders : official journal of the Movement Disorder Society 20210504 8

<h4>Background</h4>Cerebrospinal fluid (CSF) levels of monoamine metabolites may represent biomarkers of Parkinson's disease (PD).<h4>Objective</h4>The aim of this study was quantification of multiple metabolites in CSF from PD versus healthy control subjects (HCs), including longitudinal analysis.<h4>Methods</h4>Absolute levels of multiple monoamine metabolites in CSF were quantified by liquid chromatography coupled with tandem mass spectrometry from 161 individuals with early PD and 115 HCs fr ...[more]

PMID: 33942926

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Dataset Information

Longitudinal Analysis of Multiple Neurotransmitter Metabolites in Cerebrospinal Fluid in Early Parkinson's Disease.

Background

Objective

Methods

Results

Conclusions

Publications

Longitudinal Analysis of Multiple Neurotransmitter Metabolites in Cerebrospinal Fluid in Early Parkinson's Disease.

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