Diagnostic accuracy of fibrosis tests in children with non-alcoholic fatty liver disease: A systematic review.

ABSTRACT:

Background & aims

Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in children. Even at young age, it can progress to liver fibrosis. Given the drawbacks of liver biopsy, there is a need for non-invasive methods to accurately stage liver fibrosis in this age group. In this systematic review, we evaluate the diagnostic accuracy of non-invasive methods for staging liver fibrosis in children with NAFLD.

Methods

We searched MEDLINE, Embase, Web of Science and the Cochrane Library, for studies that evaluated the performance of a blood-based biomarker, prediction score or imaging technique in staging liver fibrosis in children with NAFLD, using liver biopsy as the reference standard.

Results

Twenty studies with a total of 1787 NAFLD

SUBMITTER: Draijer LG 

PROVIDER: S-EPMC8453517 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature