Signalling of multiple interleukin (IL)-17 family cytokines via IL-17 receptor A drives psoriasis-related inflammatory pathways.

ABSTRACT:

Background

The interleukin (IL)-23/IL-17 immune axis is of central importance in psoriasis. However, the impact of IL-17 family cytokines other than IL-17A in psoriasis has not been fully established.

Objectives

To elucidate the contribution of IL-17 family cytokines in psoriasis.

Methods

To address the expression and localization of IL-17 family cytokines, lesional and nonlesional skin samples from patients with psoriasis were analysed by several complementary methods, including quantitative polymerase chain reaction, immunoassays, in situ hybridization and immunohistochemistry. Mechanistic studies assessing the functional activity of IL-17 family cytokines were performed using ex vivo cultured human skin biopsies and primary human keratinocytes.

Results

We de

SUBMITTER: Tollenaere MAX 

PROVIDER: S-EPMC8453543 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature