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Late-Stage C-H Acylation of Tyrosine-Containing Oligopeptides with Alcohols.

ABSTRACT: The selective tagging of amino acids within a peptide framework while using atom-economical C-H counterparts poses an unmet challenge within peptide chemistry. Herein, we report a novel Pd-catalyzed late-stage C-H acylation of a collection of Tyr-containing peptides with alcohols. This water-compatible labeling technique is distinguished by its reliable scalability and features the use of ethanol as a renewable feedstock for the assembly of a variety of peptidomimetics.

SUBMITTER: Urruzuno I

PROVIDER: S-EPMC8453636 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Late-Stage C-H Acylation of Tyrosine-Containing Oligopeptides with Alcohols.

Urruzuno Iñaki I Andrade-Sampedro Paula P Correa Arkaitz A

Organic letters 20210903 18

The selective tagging of amino acids within a peptide framework while using atom-economical C-H counterparts poses an unmet challenge within peptide chemistry. Herein, we report a novel Pd-catalyzed late-stage C-H acylation of a collection of Tyr-containing peptides with alcohols. This water-compatible labeling technique is distinguished by its reliable scalability and features the use of ethanol as a renewable feedstock for the assembly of a variety of peptidomimetics. ...[more]

PMID: 34477386

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