Use of Autologous Stem Cells in Lumbar Spinal Fusion: A Systematic Review of Current Clinical Evidence.

ABSTRACT:

Study design

Systematic review.

Objectives

To systematically review, critically appraise and synthesize evidence on use of autologous stem cells sources for fusion in the lumbar spine.

Methods

A systematic search of PubMed/MEDLINE, EMBASE and ClinicalTrials.gov through February 20, 2020 was conducted comparing autologous cell grafts to other biologics for lumbar spine fusion. The focus was on studies comparing distinct patient groups.

Results

From 343 potentially relevant citations, 15 studies met the inclusion criteria set a priori. Seven studies compared distinct patient groups, with BMA being used in combination with allograft or autograft not as a standalone material. No economic evaluations were identified. Most observational studies were at moderately hig

SUBMITTER: Buser Z 

PROVIDER: S-EPMC8453670 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature