Ontology highlight
ABSTRACT:
SUBMITTER: Coffman J
PROVIDER: S-EPMC8453788 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Coffman Jon J Bibbo Kenneth K Brower Mark M Forbes Robert R Guros Nicholas N Horowski Brian B Lu Rick R Mahajan Rajiv R Patil Ujwal U Rose Steven S Shultz Joseph J
Biotechnology and bioengineering 20210511 9
An 8 ton per year manufacturing facility is described based on the framework for integrated and continuous bioprocessing (ICB) common to all known biopharmaceutical implementations. While the output of this plant rivals some of the largest fed-batch plants in the world, the equipment inside the plant is relatively small: the plant consists of four 2000 L single-use bioreactors and has a maximum flow rate of 13 L/min. The equipment and facility for the ICB framework is described in sufficient det ...[more]