Induction of stable human FOXP3⁺ Tregs by a parasite-derived TGF-β mimic.

ABSTRACT: Immune homeostasis in the intestine is tightly controlled by FOXP3⁺ regulatory T cells (Tregs), defects of which are linked to the development of chronic conditions, such as inflammatory bowel disease (IBD). As a mechanism of immune evasion, several species of intestinal parasites boost Treg activity. The parasite Heligmosomoides polygyrus is known to secrete a molecule (Hp-TGM) that mimics the ability of TGF-β to induce FOXP3 expression in CD4⁺ T cells. The study aimed to investigate whether Hp-TGM could induce human FOXP3⁺ Tregs as a potential therapeutic approach for inflammatory diseases. CD4⁺ T cells from healthy volunteers were expanded in the presence of Hp-TGM or TGF-β. Treg induction was measured by flow cytometric detection of FOXP3 and

SUBMITTER: Cook L 

PROVIDER: S-EPMC8453874 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature