Increased miR-21-3p and miR-487b-3p serum levels during anaphylactic reaction in food allergic children.

ABSTRACT:

Background

Anaphylaxis is the most severe manifestation of allergic disorders. The poor knowledge of its molecular mechanisms often leads to under-diagnosis. MicroRNAs (miRNA) regulate physiologic and pathologic processes, and they have been postulated as promising diagnostic markers. The main objectives of this study were to characterize the human miRNA profile during anaphylaxis and to assess their capacity as diagnostic markers and determine their participation in the molecular mechanisms of this event.

Methods

The miRNA serum profiles from the acute and baseline phase of 5 oral food-challenged anaphylactic children (<18 years old) were obtained by next-generation sequencing (NGS). From the panel of statistically significant miRNAs obtained, several candidates were select

SUBMITTER: Nunez-Borque E 

PROVIDER: S-EPMC8453890 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature