Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource.

ABSTRACT:

Background

Whole-genome sequencing data are available from several large studies across a variety of diseases and traits. However, massive storage and computation resources are required to use these data, and to achieve sufficient power for discoveries, harmonization of multiple cohorts is critical.

Objectives

The Accelerating Medicines Partnership Parkinson's Disease program has developed a research platform for Parkinson's disease (PD) that integrates the storage and analysis of whole-genome sequencing data, RNA expression data, and clinical data, harmonized across multiple cohort studies.

Methods

The version 1 release contains whole-genome sequencing data derived from 3941 participants from 4 cohorts. Samples underwent joint genotyping by the TOPMed Freeze 9 Varian

SUBMITTER: Iwaki H 

PROVIDER: S-EPMC8453903 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature