Fluid balance-adjusted creatinine in diagnosing acute kidney injury in the critically ill.

ABSTRACT:

Background

Acute kidney injury (AKI) is often diagnosed based on plasma creatinine (Cr) only. Adjustment of Cr for cumulative fluid balance due to potential dilution of Cr and subsequently missed Cr-based diagnosis of AKI has been suggested, albeit the physiological rationale for these adjustments is questionable. Furthermore, whether these adjustments lead to a different incidence of AKI when used in conjunction with urine output (UO) criteria is unknown.

Methods

This was a post hoc analysis of the Finnish Acute Kidney Injury study. Hourly UO and daily plasma Cr were measured during the first 5 days of intensive care unit admission. Cr values were adjusted following the previously used formula and combined with the UO criteria. Resulting incidences and mortality rates were

SUBMITTER: Tornblom S 

PROVIDER: S-EPMC8453932 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature