Chromatin accessibility and regulatory vocabulary across indicine cattle tissues.

ABSTRACT:

Background

Spatiotemporal changes in the chromatin accessibility landscape are essential to cell differentiation, development, health, and disease. The quest of identifying regulatory elements in open chromatin regions across different tissues and developmental stages is led by large international collaborative efforts mostly focusing on model organisms, such as ENCODE. Recently, the Functional Annotation of Animal Genomes (FAANG) has been established to unravel the regulatory elements in non-model organisms, including cattle. Now, we can transition from prediction to validation by experimentally identifying the regulatory elements in tropical indicine cattle. The identification of regulatory elements, their annotation and comparison with the taurine counterpart, holds high promise

SUBMITTER: Alexandre PA 

PROVIDER: S-EPMC8454054 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature