Reproductive tract microbiota of women in childbearing age shifts upon gynecological infections and menstrual cycle.

ABSTRACT:

Background

This study was undertaken to discover whether the vaginal microbe of women at childbearing age is different among groups defined by urogenital tract infections, childbearing history and menstrual cycle, respectively.

Results

This was a multiple case-control study of women at childbearing age who were assigned to case or control groups according to their states of urogenital tract infections. The participants were also grouped by childbearing history and menstrual cycle. Vaginal swabs were collected and stored at - 70 °C until assayed. The V3-V4 region of 16S rRNA gene was amplified using PCR and sequenced on the Illumina MiSeq platform. We tested the hypothesis of whether the relative abundance of microbial species in vaginal microbiota was varied with urogenital

SUBMITTER: Cheng L 

PROVIDER: S-EPMC8454066 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature