Dataset Information
Accelerated complete human skin architecture restoration after wounding by nanogenerator-driven electrostimulation.
Ontology highlight
ABSTRACT: Background
Electrostimulation (ES) therapy for wound healing is limited in clinical use due to barriers such as cumbersome equipment and intermittent delivery of therapy.Methods
We adapted a human skin xenograft model that can be used to directly examine the nanogenerator-driven ES (NG-ES) effects on human skin in vivo-an essential translational step toward clinical application of the NG-ES technique for wound healing.Results
We show that NG-ES leads to rapid wound closure with complete restoration of normal skin architecture within 7 days compared to more than 30 days in the literature. NG-ES accelerates the inflammatory phase of wound healing with more rapid resolution of neutrophils and macrophages and enhances wound bed perfusion with more robust neovascularization.Conclusion
Our results support the translational evaluation and optimization of the NG-ES technology to deliver convenient, efficient wound healing therapy for use in human wounds.
SUBMITTER: Liu A
PROVIDER: S-EPMC8454068 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Accelerated complete human skin architecture restoration after wounding by nanogenerator-driven electrostimulation.
Journal of nanobiotechnology 20210920 1
<h4>Background</h4>Electrostimulation (ES) therapy for wound healing is limited in clinical use due to barriers such as cumbersome equipment and intermittent delivery of therapy.<h4>Methods</h4>We adapted a human skin xenograft model that can be used to directly examine the nanogenerator-driven ES (NG-ES) effects on human skin in vivo-an essential translational step toward clinical application of the NG-ES technique for wound healing.<h4>Results</h4>We show that NG-ES leads to rapid wound closur ...[more]