Constructing xenobiotic maps of metabolism to predict enzymes catalyzing metabolites capable of binding to DNA.

ABSTRACT:

Background

The liver plays a major role in the metabolic activation of xenobiotics (drugs, chemicals such as pollutants, pesticides, food additives...). Among environmental contaminants of concern, heterocyclic aromatic amines (HAA) are xenobiotics classified by IARC as possible or probable carcinogens (2A or 2B). There exist little information about the effect of these HAA in humans. While HAA is a family of more than thirty identified chemicals, the metabolic activation and possible DNA adduct formation have been fully characterized in human liver for only a few of them (MeIQx, PhIP, A[Formula: see text]C).

Results

We have developed a modeling approach in order to predict all the possible metabolites of a xenobiotic and enzymatic profiles that are linked to the production

SUBMITTER: Conan M 

PROVIDER: S-EPMC8454073 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature