The role of interferon regulatory factor 8 for retinal tissue homeostasis and development of choroidal neovascularisation.

ABSTRACT:

Background

Microglia cells represent the resident innate immune cells of the retina and are important for retinal development and tissue homeostasis. However, dysfunctional microglia can have a negative impact on the structural and functional integrity of the retina under native and pathological conditions.

Methods

In this study, we examined interferon-regulatory factor 8 (Irf8)-deficient mice to determine the transcriptional profile, morphology, and temporospatial distribution of microglia lacking Irf8 and to explore the effects on retinal development, tissue homeostasis, and formation of choroidal neovascularisation (CNV).

Results

Our study shows that Irf8-deficient MG exhibit a considerable loss of microglial signature genes accompanied by a severely altered MG mor

SUBMITTER: Zhang P 

PROVIDER: S-EPMC8454118 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature