The transcription factor reservoir and chromatin landscape in activated plasmacytoid dendritic cells.

ABSTRACT:

Background

Transcription factors (TFs) control gene expression by direct binding to regulatory regions of target genes but also by impacting chromatin landscapes and modulating DNA accessibility for other TFs. In recent years several TFs have been defined that control cell fate decisions and effector functions in the immune system. Plasmacytoid dendritic cells (pDCs) are an immune cell type with the unique capacity to produce high amounts of type I interferons quickly in response to contact with viral components. Hereby, this cell type is involved in anti-infectious immune responses but also in the development of inflammatory and autoimmune diseases. To date, the global TF reservoir in pDCs early after activation remains to be fully characterized.

Results

To fill this gap, w

SUBMITTER: Mann-Nuttel R 

PROVIDER: S-EPMC8454182 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature