Characterizing cleft palate toxicants using ToxCast data, chemical structure, and the biomedical literature.

ABSTRACT: Cleft palate has been linked to both genetic and environmental factors that perturb key events during palatal morphogenesis. As a developmental outcome, it presents a challenging, mechanistically complex endpoint for predictive modeling. A data set of 500 chemicals evaluated for their ability to induce cleft palate in animal prenatal developmental studies was compiled from Toxicity Reference Database and the biomedical literature, which included 63 cleft palate active and 437 inactive chemicals. To characterize the potential molecular targets for chemical-induced cleft palate, we mined the ToxCast high-throughput screening database for patterns and linkages in bioactivity profiles and chemical structural descriptors. ToxCast assay results were filtered for cytotoxicity and grouped by targe

SUBMITTER: Baker NC 

PROVIDER: S-EPMC8454266 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature