Role of adolescent-formed, context-drug-associations on reinstatement of drug-seeking behavior in rats.

ABSTRACT:

Rationale

Drug use during adolescence results in a lifelong risk to develop substance-use disorders. Adolescent rats are less reactive to cocaine-associated cues compared with adults; however, the contribution of adolescent-formed, context-drug-associations to elicit relapse-like behavior is underexplored. Although it is known that social isolation can impact drug-seeking behavior, the effects of housing conditions on context-induced, cocaine-seeking during adolescence vs adulthood are unknown.

Objectives

The present study compared the effect of adolescent vs adult-formed context-drug associations under different housing conditions (pair vs single) on cocaine-seeking behavior during adolescence or adulthood. This objective was accomplished using operant cocaine self-administ

SUBMITTER: Cho BR 

PROVIDER: S-EPMC8454267 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature