Partial volume correction analysis for ¹¹C-UCB-J PET studies of Alzheimer's disease.

ABSTRACT:

Purpose

¹¹C-UCB-J PET imaging, targeting synaptic vesicle glycoprotein 2A (SV2A), has been shown to be a useful indicator of synaptic density in Alzheimer's disease (AD). For SV2A imaging, a decrease in apparent tracer uptake is often due to the combination of gray-matter (GM) atrophy and SV2A decrease in the remaining tissue. Our aim is to reveal the true SV2A change by performing partial volume correction (PVC).

Methods

We performed two PVC algorithms, Müller-Gärtner (MG) and 'iterative Yang' (IY), on 17 AD participants and 11 cognitive normal (CN) participants using the brain-dedicated HRRT scanner. Distribution volume V_T, the rate constant K₁, binding potential BP_ND (centrum semiovale as reference region), and tissue volume wer

SUBMITTER: Lu Y 

PROVIDER: S-EPMC8454285 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature