Ontology highlight
ABSTRACT:
SUBMITTER: Gregory MD
PROVIDER: S-EPMC8454493 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Gregory Michael D MD Eisenberg Daniel P DP Hamborg Madeline M Kippenhan J Shane JS Kohn Philip P Kolachana Bhaskar B Dickinson Dwight D Berman Karen F KF
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20210701 5
Schizophrenia has been hypothesized to be a human-specific condition, but experimental approaches to testing this idea have been limited. Because Neanderthals, our closest evolutionary relatives, interbred with modern humans prior to their disappearance from the fossil record, leaving a residual echo that survives in our DNA today, we leveraged new discoveries about ancient hominid DNA to explore this hypothesis in living people in three converging ways. First, in four independent case-control d ...[more]