Roxadustat Does Not Affect Platelet Production, Activation, and Thrombosis Formation.
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ABSTRACT:
SUBMITTER: Zhao J
PROVIDER: S-EPMC8454499 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
Roxadustat Does Not Affect Platelet Production, Activation, and Thrombosis Formation.
Zhao Jiaxin J Xu Yanyan Y Xie Jingyuan J Liu Junling J Zhang Ruiyan R Yan Xiaoxiang X
Arteriosclerosis, thrombosis, and vascular biology 20210805 10
Objective: Roxadustat is a new medication for the treatment of renal anemia. EPO (erythropoietin)-the current treatment standard-has been reported to enhance platelet activation and production. However, to date, the effect of roxadustat on platelets is unclear. To address this deficiency, herein, we have evaluated the effect of roxadustat on platelet production and function. Approach and Results: We performed several mouse platelet functional assays in the presence/absence of in vitro and in vi ...[more]
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