Overexpression of IRF3 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma.

ABSTRACT:

Background

Growing findings have demonstrated that interferon regulatory transcription factor (IRF) family members are linked to the progression of various cancers. However, the roles of IRFs in clear cell renal cell carcinoma (ccRCC) remain undefined. Herein, we conducted a comprehensive analysis using the bioinformatics method to evaluate the expression patterns, clinical significance, and regulation of IRFs-related mechanisms in patients with ccRCC.

Methods

Data from the Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGA), and Gene Expression Omnibus (GEO) databases were used for investigation comprehensively. Specifically, we carried out a series of analyses to identify the candidate IRF and to explore its potential action mechanisms using the gene

SUBMITTER: Wu J 

PROVIDER: S-EPMC8454526 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature