A distinct association of inflammatory molecules with outcomes of COVID-19 in younger versus older adults.
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ABSTRACT:
SUBMITTER: Shin JJ
PROVIDER: S-EPMC8455237 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
A distinct association of inflammatory molecules with outcomes of COVID-19 in younger versus older adults.
Shin Junghee J JJ Jeon Sangchoon S Unlu Serhan S Par-Young Jennefer J Shin Min Sun MS Kuster John K JK Afinogenova Yuliya Y Kang Yumi Y Simonov Michael M Buller Gregory G Bucala Richard R Kang Insoo I
Clinical immunology (Orlando, Fla.) 20210922
Aging can alter immunity affecting host defense. COVID-19 has the most devastating clinical outcomes in older adults, raising the implication of immune aging in determining its severity and mortality. We investigated biological predictors for clinical outcomes in a dataset of 13,642 ambulatory and hospitalized adult COVID-19 patients, including younger (age < 65, n = 566) and older (age ≥ 65, n = 717) subjects, with in-depth analyses of inflammatory molecules, cytokines and comorbidities. Diseas ...[more]
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