Missing Self-Induced Microvascular Rejection of Kidney Allografts: A Population-Based Study.

ABSTRACT:

Background

Circulating anti-HLA donor-specific antibodies (HLA-DSA) are often absent in kidney transplant recipients with microvascular inflammation (MVI). Missing self, the inability of donor endothelial cells to provide HLA I-mediated signals to inhibitory killer cell Ig-like receptors (KIRs) on recipient natural killer cells, can cause endothelial damage in vitro, and has been associated with HLA-DSA-negative MVI. However, missing self's clinical importance as a nonhumoral trigger of allograft rejection remains unclear.

Methods

In a population-based study of 924 consecutive kidney transplantations between March 2004 and February 2013, we performed high-resolution donor and recipient HLA typing and recipient KIR genotyping. Missing self was defined as the absence of

SUBMITTER: Callemeyn J 

PROVIDER: S-EPMC8455279 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature