Effects of adiposity on the human plasma proteome: observational and Mendelian randomisation estimates.

ABSTRACT:

Background

Variation in adiposity is associated with cardiometabolic disease outcomes, but mechanisms leading from this exposure to disease are unclear. This study aimed to estimate effects of body mass index (BMI) on an extensive set of circulating proteins.

Methods

We used SomaLogic proteomic data from up to 2737 healthy participants from the INTERVAL study. Associations between self-reported BMI and 3622 unique plasma proteins were explored using linear regression. These were complemented by Mendelian randomisation (MR) analyses using a genetic risk score (GRS) comprised of 654 BMI-associated polymorphisms from a recent genome-wide association study (GWAS) of adult BMI. A disease enrichment analysis was performed using DAVID Bioinformatics 6.8 for proteins which were alte

SUBMITTER: Goudswaard LJ 

PROVIDER: S-EPMC8455324 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature