Cord blood metabolic signatures predictive of childhood overweight and rapid growth.

ABSTRACT:

Introduction

Metabolomics may identify biological pathways predisposing children to the risk of overweight and obesity. In this study, we have investigated the cord blood metabolic signatures of rapid growth in infancy and overweight in early childhood in four European birth cohorts.

Methods

Untargeted liquid chromatography-mass spectrometry metabolomic profiles were measured in cord blood from 399 newborns from four European cohorts (ENVIRONAGE, Rhea, INMA and Piccolipiu). Rapid growth in the first year of life and overweight in childhood was defined with reference to WHO growth charts. Metabolome-wide association scans for rapid growth and overweight on over 4500 metabolic features were performed using multiple adjusted logistic mixed-effect models and controlling the fals

SUBMITTER: Handakas E 

PROVIDER: S-EPMC8455328 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature