Retroviral gene therapy in Germany with a view on previous experience and future perspectives.

ABSTRACT: Gene therapy can be used to restore cell function in monogenic disorders or to endow cells with new capabilities, such as improved killing of cancer cells, expression of suicide genes for controlled elimination of cell populations, or protection against chemotherapy or viral infection. While gene therapies were originally most often used to treat monogenic diseases and to improve hematopoietic stem cell transplantation outcome, the advent of genetically modified immune cell therapies, such as chimeric antigen receptor modified T cells, has contributed to the increased numbers of patients treated with gene and cell therapies. The advancement of gene therapy with integrating retroviral vectors continues to depend upon world-wide efforts. As the topic of this special issue is "Spotlight on Ge

SUBMITTER: Morgan MA 

PROVIDER: S-EPMC8455336 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature