Systematic tissue collection during clinical breast biopsy is feasible, safe and enables high-content translational analyses.

ABSTRACT: Systematic collection of fresh tissues for research at the time of diagnostic image-guided breast biopsy has the potential to fuel a wide variety of innovative studies. Here we report the initial experience, including safety, feasibility, and laboratory proof-of-principle, with the collection and analysis of research specimens obtained via breast core needle biopsy immediately following routine clinical biopsy at a single institution over a 14-month period. Patients underwent one or two additional core biopsies following collection of all necessary clinical specimens. In total, 395 patients were approached and 270 consented to the research study, yielding a 68.4% consent rate. Among consenting patients, 238 lesions were biopsied for research, resulting in 446 research specimens collected.

SUBMITTER: Koh SB 

PROVIDER: S-EPMC8455592 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature