Berkchaetoazaphilone B has antimicrobial activity and affects energy metabolism.

ABSTRACT: Antimicrobial resistance has become one of the major threats to human health. Therefore, there is a strong need for novel antimicrobials with new mechanisms of action. The kingdom of fungi is an excellent source of antimicrobials for this purpose because it encompasses countless fungal species that harbor unusual metabolic pathways. Previously, we have established a library of secondary metabolites from 10,207 strains of fungi. Here, we screened for antimicrobial activity of the library against seven pathogenic bacterial strains and investigated the identity of the active compounds using ethyl acetate extraction, activity-directed purification using HPLC fractionation and chemical analyses. We initially found 280 antimicrobial strains and subsequently identified 17 structurally distinct co

SUBMITTER: Ouyang X 

PROVIDER: S-EPMC8455593 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature