Myeloid and Mesenchymal Stem Cell Therapies for Solid Organ Transplant Tolerance.

ABSTRACT: Transplantation is now performed globally as a routine procedure. However, the increased demand for donor organs and consequent expansion of donor criteria has created an imperative to maximize the quality of these gains. The goal is to balance preservation of allograft function against patient quality-of-life, despite exposure to long-term immunosuppression. Elimination of immunosuppressive therapy to avoid drug toxicity, with concurrent acceptance of the allograft-so-called operational tolerance-has proven elusive. The lack of recent advances in immunomodulatory drug development, together with advances in immunotherapy in oncology, has prompted interest in cell-based therapies to control the alloimmune response. Extensive experimental work in animals has characterized regulatory immune c

SUBMITTER: Li J 

PROVIDER: S-EPMC8455706 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature