Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets.

ABSTRACT:

Objective

Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium.

Methods

We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries.

Results

There w

SUBMITTER: Postema MC 

PROVIDER: S-EPMC8455726 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature