Changes in the Gut Microbiome Contribute to the Development of Behcet's Disease via Adjuvant Effects.

ABSTRACT: Behcet's disease (BD) is associated with considerable gut microbiome changes. However, it still remains unknown how the composition of the gut microbiome exactly affects the development of this disease. In this study, transplantation of stool samples from patients with active ocular BD to mice via oral gavage was performed. This resulted in decreases of three short chain fatty acids (SCFAs) including butyric acid, propionic acid and valeric acid in the feces of the BD-recipient group. Intestinal barrier integrity of mice receiving BD feces was damaged as shown by a decreased expression of tight junction proteins and was associated with the release of Lipopolysaccharides (LPS) in the circulation. The mice also showed a higher frequency of splenic neutrophils as well as an enrichment

SUBMITTER: Wang Q 

PROVIDER: S-EPMC8455896 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature