A Five-Gene-Based Prognostic Signature for Hepatocellular Carcinoma.

ABSTRACT: Objective: This study intends to identify potential prognostic marker genes associated with the prognosis of patients suffering from hepatocellular carcinoma (HCC) based on TCGA and GEO analysis. Methods: TCGA-LIHC cohort was downloaded and the data related to HCC were extracted from The Cancer Genome Atlas (TCGA) database and subjected to differential analysis. HCC-related gene expression datasets were retrieved from the GEO database, followed by differential analysis. After intersection of the results of TCGA and GEO databases, gene interaction analysis was performed to obtain the core genes. To identify the genes related to the prognosis of HCC patients, we conducted univariate and multivariate Cox analyses. Results: Based on differential analysis of TCGA database,

SUBMITTER: Tian D 

PROVIDER: S-EPMC8455941 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature