GH Overexpression Alters Spermatic Cells MicroRNAome Profile in Transgenic Zebrafish.

ABSTRACT: Overexpression of growth hormone (GH) in gh-transgenic zebrafish of a highly studied lineage F0104 has earlier been reported to cause increased muscle growth. In addition to this, GH affects a broad range of cellular processes in transgenic fish, such as morphology, physiology, and behavior. Reports show changes such as decreased sperm quality and reduced reproductive performance in transgenic males. It is hypothesized that microRNAs are directly involved in the regulation of fertility potential during spermatogenesis. The primary aim of our study was to verify whether gh overexpression disturbs the sperm miRNA profile and influences the sperm quality in transgenic zebrafish. We report a significant increase in body weight of gh-transgenic males along with associated r

SUBMITTER: Domingues WB 

PROVIDER: S-EPMC8455951 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature