Preliminary Evaluations of [¹¹C]Verubulin: Implications for Microtubule Imaging With PET.

ABSTRACT: [¹¹C]Verubulin (a.k.a.[¹¹C]MCP-6827), [¹¹C]HD-800 and [¹¹C]colchicine have been developed for imaging microtubules (MTs) with positron emission tomography (PET). The objective of this work was to conduct an in vivo comparison of [¹¹C]verubulin for MT imaging in mouse and rat brain, as well as an in vitro study with this radiotracer in rodent and human Alzheimer's Disease tissue. Our preliminary PET imaging studies of [¹¹C]verubulin in rodents revealed contradictory results between mouse and rat brain uptake under pretreatment conditions. In vitro autoradiography with [¹¹C]verubulin showed an unexpected higher uptake in AD patient tissue compared with healthy controls. We also conducted the fir

SUBMITTER: Lindberg A 

PROVIDER: S-EPMC8456034 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature