Association Between Neonatal Thyroid Function and Anogenital Distance from Birth to 48 Months of Age.

ABSTRACT:

Background

Evidence from animal studies has indicated that neonatal thyroid function is vital for the reproductive development. Anogenital distance (AGD), a sensitive biomarker of the fetal hormonal milieu, can be used to predict adult reproductive disorders. However, few human studies have examined the association between neonatal thyroid function and AGD. We aimed to explore their associations in a birth cohort study.

Methods

Concentrations of thyroid stimulating hormone (TSH) and thyroid hormones (THs), including total triiodothyronine (TT₃), total thyroxine (TT₄), free triiodothyronine (FT₃), and free thyroxine (FT₄) were measured in cord plasma in the Shanghai-Minhang Birth Cohort. The offspring AGD (AGD_AP [anus-pen

SUBMITTER: Luan M 

PROVIDER: S-EPMC8456038 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature