Latent TGFβ-binding proteins regulate UCP1 expression and function via TGFβ2.

ABSTRACT:

Objective

Activation of brown adipose tissue (BAT) in humans has been proposed as a new treatment approach for combating obesity and its associated diseases, as BAT participates in the regulation of energy homeostasis as well as glucose and lipid metabolism. Genetic contributors driving brown adipogenesis in humans have not been fully understood.

Methods

Profiling the gene expression of progenitor cells from subcutaneous and deep neck adipose tissue, we discovered new secreted factors with potential regulatory roles in white and brown adipogenesis. Among these, members of the latent transforming growth factor beta-binding protein (LTBP) family were highly expressed in brown compared to white adipocyte progenitor cells, suggesting that these proteins are capable of promoting

SUBMITTER: Halbgebauer D 

PROVIDER: S-EPMC8456047 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature