Advances in neural organoid systems and their application in neurotoxicity testing of environmental chemicals.

ABSTRACT: Due to the complex structure and function of central nervous system (CNS), human CNS in vitro modeling is still a great challenge. Neurotoxicity testing of environmental chemicals mainly depends on the traditional animal models, which have various limitations such as species differences, expensive and time-consuming. Meanwhile, in vitro two-dimensional (2D) cultured cells or three-dimensional (3D) cultured neurospheres cannot fully simulate complex 3D structure of neural tissues. Recent advancements in neural organoid systems provides excellent models for the testing of environmental chemicals that affect the development of human CNS. Neural organoids derived from hPSCs not only can simulate the process of CNS development, including early stage neural tube formation, neuroepithelium differ

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC8456188 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature