Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABA_A R-Dependent TRIM21 Modulation of Src Expression.

ABSTRACT: Generation of circulating tumor cells (CTCs), a key step in tumor metastasis, occurs during surgical tumor resection, often performed under general anesthesia. Propofol is the commonly used anesthetic, but its effects on CTCs and tumor metastasis remain largely unknown. Propofol effects are investigated in an experimental metastasis model by injecting tumor cells and, subsequently, low- or standard-dose propofol to nude mice through tail vein. Propofol- or vehicle-treated tumor cells are also injected to the mice. An in vitro tumor cell-vascular endothelial cell adhesion assay, immunofluorescence, and other methods are employed to assess how propofol affects tumor cell adhesion and extension. Propofol induces more lung tumor metastasis in mice than control. Mechanistically, propofol enhanc

SUBMITTER: Liu Q 

PROVIDER: S-EPMC8456212 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature