Association of Midlife Plasma Amyloid-β Levels With Cognitive Impairment in Late Life: The ARIC Neurocognitive Study.

ABSTRACT:

Background and objectives

To evaluate the association between midlife plasma amyloid-β (Aβ_1-42, Aβ_1-40, Aβ₄₂:Aβ₄₀) and risk of mild cognitive impairment (MCI) and dementia.

Methods

Plasma Aβ₄₂ and Aβ₄₀ were retrospectively measured with a fluorometric bead-based immunoassay in a subsample of the Atherosclerosis Risk in Communities cohort study. We investigated the relationship of plasma Aβ₄₂, Aβ₄₀, and Aβ₄₂:Aβ₄₀ ratio measured in midlife and late life and the change from midlife to late life to risk of MCI, dementia, and combined MCI/dementia outcomes in late life (from 2011-2019). We used multinomial logistic regressions estimating relative risk ratios (RRRs) of the

SUBMITTER: Sullivan KJ 

PROVIDER: S-EPMC8456355 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature